Detailed information of TA system TA193709

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1047612..1047857
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: JRC41_RS04950
• Protein ID: WP_000956458.1
• Coordinates: 1047705..1047857 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	1047612..1047660 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS04935	1043016..1044815	+	1800	WP_059241923.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
JRC41_RS04940	1044815..1046527	+	1713	WP_059235907.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
JRC41_RS04945	1046707..1047441	+	735	WP_059235904.1	phosphoadenosine phosphosulfate reductase	-
-	1047612..1047660	-	49	-	-	Antitoxin
JRC41_RS04950	1047705..1047857	+	153	WP_000956458.1	Hok/Gef family protein	Toxin
JRC41_RS04955	1047982..1049019	-	1038	WP_059235902.1	alkaline phosphatase isozyme conversion aminopeptidase	-
JRC41_RS04960	1049273..1050181	+	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
JRC41_RS04965	1050183..1051610	+	1428	WP_054412002.1	sulfate adenylyltransferase subunit CysN	-
JRC41_RS04970	1051610..1052215	+	606	WP_024164730.1	adenylyl-sulfate kinase	-
JRC41_RS04975	1052265..1052588	+	324	WP_001246114.1	DUF3561 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T193709 WP_000956458.1 NZ_CP070290:1047705-1047857 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T193709 NZ_CP093173:1027010-1027189 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT193709 NZ_CP070290:c1047660-1047612 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin