Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 635029..635756 Replicon chromosome
Accession NZ_CP070290
Organism Escherichia albertii strain Sample 167

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag JRC41_RS03100 Protein ID WP_000550189.1
Coordinates 635029..635343 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JRC41_RS03105 Protein ID WP_000560272.1
Coordinates 635340..635756 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC41_RS03080 (631188) 631188..632174 - 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -
JRC41_RS03085 (632253) 632253..632945 - 693 WP_059215025.1 vancomycin high temperature exclusion protein -
JRC41_RS03090 (633022) 633022..633525 - 504 WP_059215024.1 M48 family metallopeptidase -
JRC41_RS03095 (633610) 633610..634746 + 1137 WP_059241776.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
JRC41_RS03100 (635029) 635029..635343 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
JRC41_RS03105 (635340) 635340..635756 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JRC41_RS03110 (635846) 635846..637864 - 2019 WP_059216457.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
JRC41_RS03115 (638089) 638089..640440 - 2352 WP_059235423.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T193707 WP_000550189.1 NZ_CP070290:635029-635343 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T193707 NZ_CP093173:868858-869067 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT193707 WP_000560272.1 NZ_CP070290:635340-635756 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp

>AT193707 NZ_CP093173:868558-868851 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References