Detailed information of TA system TA193706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 593347..594146
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: JRC41_RS02895
• Protein ID: WP_059235443.1
• Coordinates: 593347..593811 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: S1PPV5
• Locus tag: JRC41_RS02900
• Protein ID: WP_001296435.1
• Coordinates: 593811..594146 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS02865 (588348)	588348..588782	-	435	WP_000948824.1	PTS galactosamine/N-acetylgalactosamine transporter subunit IIA	-
JRC41_RS02870 (588800)	588800..589678	-	879	WP_001295548.1	PTS N-acetylgalactosamine transporter subunit IID	-
JRC41_RS02875 (589668)	589668..590447	-	780	WP_000406226.1	PTS N-acetylgalactosamine transporter subunit IIC	-
JRC41_RS02880 (590458)	590458..590931	-	474	WP_059218168.1	PTS N-acetylgalactosamine transporter subunit IIB	-
JRC41_RS02885 (590954)	590954..592234	-	1281	WP_059235447.1	tagatose-bisphosphate aldolase subunit KbaZ	-
JRC41_RS02890 (592483)	592483..593292	+	810	WP_059235445.1	aga operon transcriptional regulator AgaR	-
JRC41_RS02895 (593347)	593347..593811	-	465	WP_059235443.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
JRC41_RS02900 (593811)	593811..594146	-	336	WP_001296435.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
JRC41_RS02905 (594295)	594295..595866	-	1572	WP_059235441.1	galactarate dehydratase	-
JRC41_RS02910 (596237)	596237..597571	+	1335	WP_059241781.1	galactarate/glucarate/glycerate transporter GarP	-
JRC41_RS02915 (597587)	597587..598357	+	771	WP_059235438.1	2-dehydro-3-deoxyglucarate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17825.22 Da
• Isoelectric Point: 9.6804

>T193706 WP_059235443.1 NZ_CP070290:c593811-593347 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSSAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Nucleotide

• Length: 465 bp

>T193706 NZ_CP093170:2033262-2033450 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAGAGAAGAACGAAAAGAATCTTATCTAGGTTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12321.92 Da
• Isoelectric Point: 4.5392

>AT193706 WP_001296435.1 NZ_CP070290:c594146-593811 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT193706 NZ_CP093170:2032980-2033237 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATGTATTCAACTTGATATTCACCATTTTATTTTTTACATTTAACATTCTCATAACCTATAA
CGCAAATATTGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGCTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTATATTATATTTATCCGATT
TTTTATGAATTTGTCTAA

Structures

Antitoxin

• AlphaFold DB: S1PPV5