Detailed information of TA system TA193703

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 166302..166559
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: JRC41_RS00745
• Protein ID: WP_001135738.1
• Coordinates: 166407..166559 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	166302..166350 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS00725	161532..162527	-	996	WP_059235567.1	acyltransferase	-
JRC41_RS00730	162700..162999	+	300	WP_000979961.1	YsaB family lipoprotein	-
JRC41_RS00735	163095..164006	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
JRC41_RS00740	164016..166085	+	2070	WP_059235569.1	glycine--tRNA ligase subunit beta	-
-	166302..166350	-	49	-	-	Antitoxin
JRC41_RS00745	166407..166559	+	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
JRC41_RS22215	166536..166607	-	72	WP_212734940.1	hypothetical protein	-
JRC41_RS00750	166747..166959	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
JRC41_RS00755	167242..167532	-	291	WP_000455794.1	HTH-type transcriptional regulator	-
JRC41_RS00760	167955..168665	+	711	WP_208631095.1	DUF3053 domain-containing protein	-
JRC41_RS00765	168718..169692	-	975	WP_059235571.1	glyoxylate/hydroxypyruvate reductase GhrB	-
JRC41_RS00770	169796..170455	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T193703 WP_001135738.1 NZ_CP070290:166407-166559 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T193703 NZ_CP093170:878930-879139 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATACATGTTTCAGGTATTAAAACAACTGAACAAGAGAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTGGAATTTGACACTCCCGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTGCGGATTTCGTATTTTATAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT193703 NZ_CP070290:c166350-166302 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin