Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4568581..4569183 | Replicon | chromosome |
| Accession | NZ_CP070287 | ||
| Organism | Escherichia albertii strain Sample 168 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S1P416 |
| Locus tag | JRC45_RS22580 | Protein ID | WP_000897302.1 |
| Coordinates | 4568872..4569183 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JRC45_RS22575 | Protein ID | WP_000356397.1 |
| Coordinates | 4568581..4568871 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRC45_RS22535 (4564108) | 4564108..4564743 | + | 636 | WP_000829019.1 | formate dehydrogenase cytochrome b556 subunit | - |
| JRC45_RS22540 (4564740) | 4564740..4565669 | + | 930 | WP_000027704.1 | formate dehydrogenase accessory protein FdhE | - |
| JRC45_RS22545 (4565706) | 4565706..4566080 | - | 375 | WP_204628897.1 | type II toxin-antitoxin system VapC family toxin | - |
| JRC45_RS22550 (4566080) | 4566080..4566322 | - | 243 | WP_001275524.1 | CopG family transcriptional regulator | - |
| JRC45_RS22555 (4566550) | 4566550..4566768 | - | 219 | WP_001314326.1 | CopG family transcriptional regulator | - |
| JRC45_RS22565 (4567944) | 4567944..4568222 | - | 279 | WP_032278934.1 | hypothetical protein | - |
| JRC45_RS22570 (4568284) | 4568284..4568496 | - | 213 | WP_000197774.1 | hypothetical protein | - |
| JRC45_RS22575 (4568581) | 4568581..4568871 | - | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
| JRC45_RS22580 (4568872) | 4568872..4569183 | - | 312 | WP_000897302.1 | hypothetical protein | Toxin |
| JRC45_RS22585 (4569412) | 4569412..4570320 | + | 909 | WP_059239594.1 | alpha/beta hydrolase | - |
| JRC45_RS22590 (4570384) | 4570384..4571325 | - | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
| JRC45_RS22595 (4571370) | 4571370..4571807 | - | 438 | WP_000560977.1 | D-aminoacyl-tRNA deacylase | - |
| JRC45_RS22600 (4571804) | 4571804..4572676 | - | 873 | WP_000916663.1 | virulence factor BrkB family protein | - |
| JRC45_RS22605 (4572670) | 4572670..4573269 | - | 600 | WP_204628899.1 | glucose-1-phosphatase | - |
| JRC45_RS22610 (4573368) | 4573368..4574153 | - | 786 | WP_000059671.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4567010..4567513 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T193694 WP_000897302.1 NZ_CP070287:c4569183-4568872 [Escherichia albertii]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T193694 NZ_CP093154:c3800007-3799639 [Enterobacter asburiae]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT193694 WP_000356397.1 NZ_CP070287:c4568871-4568581 [Escherichia albertii]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT193694 NZ_CP093154:c3800354-3800028 [Enterobacter asburiae]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|