Detailed information of TA system TA193687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2388618..2389180
• Replicon: chromosome
• Accession: NZ_CP070287
• Organism: Escherichia albertii strain Sample 168

Toxin (Protein)

• Gene name: higB
• Uniprot ID: L4J948
• Locus tag: JRC45_RS11690
• Protein ID: WP_000605676.1
• Coordinates: 2388618..2388896 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JRC45_RS11695
• Protein ID: WP_000781369.1
• Coordinates: 2388896..2389180 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC45_RS11670 (2384599)	2384599..2385030	-	432	WP_204628481.1	OsmC family protein	-
JRC45_RS11675 (2385297)	2385297..2385434	+	138	WP_000841563.1	stationary-phase-induced ribosome-associated protein	-
JRC45_RS11680 (2385591)	2385591..2387288	+	1698	WP_059225292.1	malate dehydrogenase	-
JRC45_RS11685 (2387422)	2387422..2388432	+	1011	WP_059225293.1	alcohol dehydrogenase AdhP	-
JRC45_RS11690 (2388618)	2388618..2388896	+	279	WP_000605676.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JRC45_RS11695 (2388896)	2388896..2389180	+	285	WP_000781369.1	HigA family addiction module antitoxin	Antitoxin
JRC45_RS11700 (2389185)	2389185..2389661	-	477	WP_059225294.1	NUDIX domain-containing protein	-
JRC45_RS11705 (2389734)	2389734..2390387	-	654	WP_000045636.1	formate dehydrogenase-N subunit gamma	-
JRC45_RS11710 (2390380)	2390380..2391264	-	885	WP_208625420.1	formate dehydrogenase N subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10521.10 Da
• Isoelectric Point: 7.3562

>T193687 WP_000605676.1 NZ_CP070287:2388618-2388896 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T193687 NZ_CP093153:126024-126440 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10371.06 Da
• Isoelectric Point: 8.8567

>AT193687 WP_000781369.1 NZ_CP070287:2388896-2389180 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Nucleotide

• Length: 285 bp

>AT193687 NZ_CP093153:125797-126027 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A829G6T1