Detailed information of TA system TA193677

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1058802..1059048
• Replicon: chromosome
• Accession: NZ_CP070287
• Organism: Escherichia albertii strain Sample 168

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: JRC45_RS05090
• Protein ID: WP_000956458.1
• Coordinates: 1058896..1059048 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	1058802..1058854 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC45_RS05075	1054206..1056005	+	1800	WP_131109609.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
JRC45_RS05080	1056005..1057717	+	1713	WP_131109610.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
JRC45_RS05085	1057897..1058631	+	735	WP_001125132.1	phosphoadenosine phosphosulfate reductase	-
-	1058802..1058854	-	53	-	-	Antitoxin
JRC45_RS05090	1058896..1059048	+	153	WP_000956458.1	Hok/Gef family protein	Toxin
JRC45_RS05095	1059243..1061782	+	2540	Protein_1012	CRISPR-associated helicase Cas3'	-
JRC45_RS05100	1062056..1063093	-	1038	WP_059253936.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T193677 WP_000956458.1 NZ_CP070287:1058896-1059048 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T193677 NZ_CP093151:c1818284-1817868 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT193677 NZ_CP070287:c1058854-1058802 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin