Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 609717..610516 Replicon chromosome
Accession NZ_CP070287
Organism Escherichia albertii strain Sample 168

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag JRC45_RS03020 Protein ID WP_000347251.1
Coordinates 609717..610181 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag JRC45_RS03025 Protein ID WP_001296435.1
Coordinates 610181..610516 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC45_RS02990 (604718) 604718..605152 - 435 WP_000948821.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
JRC45_RS02995 (605170) 605170..606048 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
JRC45_RS03000 (606038) 606038..606817 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
JRC45_RS03005 (606828) 606828..607301 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
JRC45_RS03010 (607324) 607324..608604 - 1281 WP_059216469.1 tagatose-bisphosphate aldolase subunit KbaZ -
JRC45_RS03015 (608853) 608853..609662 + 810 WP_103053960.1 aga operon transcriptional regulator AgaR -
JRC45_RS03020 (609717) 609717..610181 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JRC45_RS03025 (610181) 610181..610516 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JRC45_RS03030 (610665) 610665..612237 - 1573 Protein_602 galactarate dehydratase -
JRC45_RS03035 (612608) 612608..613942 + 1335 Protein_603 galactarate/glucarate/glycerate transporter GarP -
JRC45_RS03040 (613958) 613958..614728 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T193674 WP_000347251.1 NZ_CP070287:c610181-609717 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T193674 NZ_CP093151:200101-200586 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAACCAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT193674 WP_001296435.1 NZ_CP070287:c610516-610181 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT193674 NZ_CP093151:199847-200113 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References