Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4565284..4565886 | Replicon | chromosome |
| Accession | NZ_CP070284 | ||
| Organism | Escherichia albertii strain Sample 169 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S1P416 |
| Locus tag | JRC46_RS22440 | Protein ID | WP_000897302.1 |
| Coordinates | 4565575..4565886 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JRC46_RS22435 | Protein ID | WP_000356397.1 |
| Coordinates | 4565284..4565574 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRC46_RS22395 (4560698) | 4560698..4561600 | + | 903 | WP_204619761.1 | formate dehydrogenase subunit beta | - |
| JRC46_RS22400 (4561597) | 4561597..4562232 | + | 636 | WP_000829019.1 | formate dehydrogenase cytochrome b556 subunit | - |
| JRC46_RS22405 (4562229) | 4562229..4563158 | + | 930 | WP_000027704.1 | formate dehydrogenase accessory protein FdhE | - |
| JRC46_RS22410 (4563195) | 4563195..4563554 | - | 360 | WP_204619762.1 | type II toxin-antitoxin system VapC family toxin | - |
| JRC46_RS22415 (4563554) | 4563554..4563796 | - | 243 | WP_001275524.1 | CopG family transcriptional regulator | - |
| JRC46_RS22420 (4564014) | 4564014..4564232 | - | 219 | WP_001251292.1 | CopG family transcriptional regulator | - |
| JRC46_RS22425 (4564647) | 4564647..4564925 | - | 279 | WP_001296612.1 | hypothetical protein | - |
| JRC46_RS22430 (4564987) | 4564987..4565199 | - | 213 | WP_000197774.1 | hypothetical protein | - |
| JRC46_RS22435 (4565284) | 4565284..4565574 | - | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
| JRC46_RS22440 (4565575) | 4565575..4565886 | - | 312 | WP_000897302.1 | hypothetical protein | Toxin |
| JRC46_RS22445 (4566115) | 4566115..4567023 | + | 909 | WP_204619763.1 | alpha/beta hydrolase | - |
| JRC46_RS22450 (4567087) | 4567087..4568028 | - | 942 | WP_204620272.1 | bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase | - |
| JRC46_RS22455 (4568073) | 4568073..4568510 | - | 438 | WP_000560977.1 | D-aminoacyl-tRNA deacylase | - |
| JRC46_RS22460 (4568507) | 4568507..4569379 | - | 873 | WP_204619764.1 | virulence factor BrkB family protein | - |
| JRC46_RS22465 (4569373) | 4569373..4569972 | - | 600 | WP_204619765.1 | glucose-1-phosphatase | - |
| JRC46_RS22470 (4570071) | 4570071..4570511 | - | 441 | Protein_4436 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4541011..4565886 | 24875 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T193664 WP_000897302.1 NZ_CP070284:c4565886-4565575 [Escherichia albertii]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T193664 NZ_CP093068:c3947039-3946641 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT193664 WP_000356397.1 NZ_CP070284:c4565574-4565284 [Escherichia albertii]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT193664 NZ_CP093068:c3947335-3947042 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|