Detailed information of TA system TA193659

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-sokC/SymE(toxin)
• Location: 4025665..4026077
• Replicon: chromosome
• Accession: NZ_CP070284
• Organism: Escherichia albertii strain Sample 169

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: JRC46_RS19885
• Protein ID: WP_204677743.1
• Coordinates: 4025736..4026077 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4025665..4025741 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC46_RS19875 (4022261)	4022261..4023730	+	1470	WP_149450978.1	type I restriction-modification system subunit M	-
JRC46_RS19880 (4023730)	4023730..4025514	+	1785	WP_208629286.1	restriction endonuclease subunit S	-
- (4025665)	4025665..4025741	-	77	NuclAT_6	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_6	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_6	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_6	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_7	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_7	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_7	-	Antitoxin
- (4025665)	4025665..4025741	-	77	NuclAT_7	-	Antitoxin
JRC46_RS19885 (4025736)	4025736..4026077	+	342	WP_204677743.1	endoribonuclease SymE	Toxin
JRC46_RS19890 (4026239)	4026239..4027617	+	1379	Protein_3934	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JRC46_RS19895 (4027617)	4027617..4028663	+	1047	WP_204619684.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
JRC46_RS19900 (4028719)	4028719..4029797	-	1079	Protein_3936	DUF1998 domain-containing protein	-
JRC46_RS19905 (4030112)	4030112..4031044	-	933	WP_204619685.1	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4018653..4042055	23402

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12354.18 Da
• Isoelectric Point: 7.8219

>T193659 WP_204677743.1 NZ_CP070284:4025736-4026077 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTTQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T193659 NZ_CP093068:c2595582-2595406 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT193659 NZ_CP070284:c4025741-4025665 [Escherichia albertii]
AGTCATGATTACTATTCCTTAGAAATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin