Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3912462..3912720 Replicon chromosome
Accession NZ_CP070284
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JRC46_RS19230 Protein ID WP_000809168.1
Coordinates 3912568..3912720 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3912462..3912519 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS19215 3908270..3909517 - 1248 WP_059227922.1 hypothetical protein -
JRC46_RS19220 3909671..3911164 - 1494 WP_059214855.1 sulfatase-like hydrolase/transferase -
JRC46_RS19225 3911185..3911946 - 762 WP_204619628.1 outer membrane protein OmpK -
- 3912462..3912519 - 58 - - Antitoxin
JRC46_RS19230 3912568..3912720 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JRC46_RS19235 3912824..3913954 - 1131 WP_204619629.1 molecular chaperone DnaJ -
JRC46_RS19240 3914043..3915959 - 1917 WP_000516135.1 molecular chaperone DnaK -
JRC46_RS19245 3916334..3916738 + 405 WP_000833521.1 DUF2541 family protein -
JRC46_RS19250 3916765..3917478 + 714 WP_001102345.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T193656 WP_000809168.1 NZ_CP070284:3912568-3912720 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T193656 NZ_CP093068:2160363-2160466 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT193656 NZ_CP070284:c3912519-3912462 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References