Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1634325..1634887 Replicon chromosome
Accession NZ_CP070284
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JRC46_RS07815 Protein ID WP_059277893.1
Coordinates 1634325..1634603 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag JRC46_RS07820 Protein ID WP_021528209.1
Coordinates 1634603..1634887 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS07795 (1630314) 1630314..1630745 - 432 WP_000152289.1 peroxiredoxin OsmC -
JRC46_RS07800 (1631003) 1631003..1631140 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
JRC46_RS07805 (1631297) 1631297..1632994 + 1698 WP_059259313.1 malate dehydrogenase -
JRC46_RS07810 (1633129) 1633129..1634139 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
JRC46_RS07815 (1634325) 1634325..1634603 + 279 WP_059277893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JRC46_RS07820 (1634603) 1634603..1634887 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
JRC46_RS07825 (1634892) 1634892..1635368 - 477 WP_059225294.1 NUDIX domain-containing protein -
JRC46_RS07830 (1635441) 1635441..1636094 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
JRC46_RS07835 (1636087) 1636087..1636971 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.12 Da        Isoelectric Point: 8.0733

>T193646 WP_059277893.1 NZ_CP070284:1634325-1634603 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCIADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GNAYILDYEDYH

Download         Length: 279 bp

>T193646 NZ_CP093067:c869649-868903 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTAGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT193646 WP_021528209.1 NZ_CP070284:1634603-1634887 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT193646 NZ_CP093067:c868903-868733 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References