Detailed information of TA system TA193643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1018555..1018801
• Replicon: chromosome
• Accession: NZ_CP070284
• Organism: Escherichia albertii strain Sample 169

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: JRC46_RS04855
• Protein ID: WP_000956458.1
• Coordinates: 1018649..1018801 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	1018555..1018607 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC46_RS04840	1013956..1015758	+	1803	WP_204677920.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
JRC46_RS04845	1015758..1017470	+	1713	WP_059273794.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
JRC46_RS04850	1017650..1018384	+	735	WP_137646802.1	phosphoadenosine phosphosulfate reductase	-
-	1018555..1018607	-	53	-	-	Antitoxin
JRC46_RS04855	1018649..1018801	+	153	WP_000956458.1	Hok/Gef family protein	Toxin
JRC46_RS04860	1018927..1019964	-	1038	WP_059268554.1	alkaline phosphatase isozyme conversion aminopeptidase	-
JRC46_RS04865	1020218..1021126	+	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
JRC46_RS04870	1021128..1022555	+	1428	WP_141109490.1	sulfate adenylyltransferase subunit CysN	-
JRC46_RS04875	1022555..1023160	+	606	WP_204620204.1	adenylyl-sulfate kinase	-
JRC46_RS04880	1023210..1023533	+	324	WP_001246114.1	DUF3561 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T193643 WP_000956458.1 NZ_CP070284:1018649-1018801 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T193643 NZ_CP093046:c993590-993282 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT193643 NZ_CP070284:c1018607-1018555 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin