Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 612734..613461 Replicon chromosome
Accession NZ_CP070284
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag JRC46_RS03005 Protein ID WP_000550189.1
Coordinates 612734..613048 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JRC46_RS03010 Protein ID WP_000560272.1
Coordinates 613045..613461 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS02985 (608893) 608893..609879 - 987 WP_204619898.1 Gfo/Idh/MocA family oxidoreductase -
JRC46_RS02990 (609958) 609958..610650 - 693 WP_000942533.1 vancomycin high temperature exclusion protein -
JRC46_RS02995 (610727) 610727..611230 - 504 WP_059225049.1 M48 family metallopeptidase -
JRC46_RS03000 (611315) 611315..612451 + 1137 WP_059254013.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
JRC46_RS03005 (612734) 612734..613048 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
JRC46_RS03010 (613045) 613045..613461 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JRC46_RS03015 (613551) 613551..615569 - 2019 WP_059216457.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
JRC46_RS03020 (615812) 615812..618163 - 2352 WP_085456624.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T193641 WP_000550189.1 NZ_CP070284:612734-613048 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T193641 NZ_CP093046:948137-948469 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT193641 WP_000560272.1 NZ_CP070284:613045-613461 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp

>AT193641 NZ_CP093046:947880-948137 [Bartonella krasnovii]
ATGTATACAACAAAATTACGTAAAGTTGGAGGGTCAGTGATGCTTTCTATACCACCTGTCTTGCTTGATGTTCTCCATCT
TACTGAAAACACACAAGTGGGCTTGGCTGTTGATAATGGACAATTGATTGTGAAGCCACAAACATTTCCAAGTTACACTC
TTGATGAATTATTAGCCCAATGTAATCCTTCAGTTGATTTTGCGGATGAGGATATAGAGTGGTTTGATGCTCAACCTGTT
GGTAGCGAGCTTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References