Detailed information of TA system TA193634

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 161517..161940
• Replicon: plasmid pESA135_2
• Accession: NZ_CP070283
• Organism: Escherichia albertii strain Sample 170

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: JRC42_RS24875
• Protein ID: WP_223200913.1
• Coordinates: 161517..161639 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	161724..161940 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC42_RS24845 (157087)	157087..157562	-	476	Protein_166	IS3 family transposase	-
JRC42_RS24850 (157726)	157726..158292	-	567	WP_204678076.1	hypothetical protein	-
JRC42_RS25400 (158428)	158428..158730	-	303	WP_244259633.1	hypothetical protein	-
JRC42_RS25405 (158727)	158727..158939	-	213	WP_244259634.1	hypothetical protein	-
JRC42_RS25410 (159289)	159289..159642	-	354	WP_244259645.1	hypothetical protein	-
JRC42_RS24865 (160116)	160116..161108	+	993	Protein_171	IS481 family transposase	-
JRC42_RS24870 (161216)	161216..161377	+	162	WP_279632107.1	Tn3 family transposase	-
JRC42_RS24875 (161517)	161517..161639	-	123	WP_223200913.1	Hok/Gef family protein	Toxin
JRC42_RS25415 (161584)	161584..161736	-	153	Protein_174	DUF5431 family protein	-
- (161724)	161724..161940	-	217	NuclAT_0	-	Antitoxin
- (161724)	161724..161940	-	217	NuclAT_0	-	Antitoxin
- (161724)	161724..161940	-	217	NuclAT_0	-	Antitoxin
- (161724)	161724..161940	-	217	NuclAT_0	-	Antitoxin
JRC42_RS24880 (161909)	161909..162671	-	763	Protein_175	plasmid SOS inhibition protein A	-
JRC42_RS24885 (162668)	162668..163102	-	435	WP_000845916.1	conjugation system SOS inhibitor PsiB	-
JRC42_RS24890 (163157)	163157..165106	-	1950	Protein_177	ParB/RepB/Spo0J family partition protein	-
JRC42_RS24895 (165172)	165172..165405	-	234	WP_000005990.1	DUF905 family protein	-
JRC42_RS24900 (165463)	165463..165942	-	480	WP_204620444.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	espC / espC	1..176494	176494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-35)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4538.38 Da
• Isoelectric Point: 8.2691

>T193634 WP_223200913.1 NZ_CP070283:c161639-161517 [Escherichia albertii]
IVCCTLLIFTLLTRNRLCEVRLKDGYREVTATMAYESGGK

Nucleotide

• Length: 123 bp

>T193634 NZ_CP093044:c884539-884255 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA

Antitoxin

Nucleotide

• Length: 217 bp

>AT193634 NZ_CP070283:c161940-161724 [Escherichia albertii]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTCTTTTCAGGAAAAGTGAGTGTGGTCAGCGCGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGC
AGAAAGCCCCGTAGTTAATTTTCATTAACCCACGAGGCCTCAGCATGTCTAGTCCAC

Structures

Antitoxin