Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4565285..4565887 | Replicon | chromosome |
| Accession | NZ_CP070281 | ||
| Organism | Escherichia albertii strain Sample 170 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S1P416 |
| Locus tag | JRC42_RS22440 | Protein ID | WP_000897302.1 |
| Coordinates | 4565576..4565887 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JRC42_RS22435 | Protein ID | WP_000356397.1 |
| Coordinates | 4565285..4565575 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRC42_RS22395 (4560699) | 4560699..4561601 | + | 903 | WP_204619761.1 | formate dehydrogenase subunit beta | - |
| JRC42_RS22400 (4561598) | 4561598..4562233 | + | 636 | WP_000829019.1 | formate dehydrogenase cytochrome b556 subunit | - |
| JRC42_RS22405 (4562230) | 4562230..4563159 | + | 930 | WP_000027704.1 | formate dehydrogenase accessory protein FdhE | - |
| JRC42_RS22410 (4563196) | 4563196..4563555 | - | 360 | WP_204619762.1 | type II toxin-antitoxin system VapC family toxin | - |
| JRC42_RS22415 (4563555) | 4563555..4563797 | - | 243 | WP_001275524.1 | CopG family transcriptional regulator | - |
| JRC42_RS22420 (4564015) | 4564015..4564233 | - | 219 | WP_001251292.1 | CopG family transcriptional regulator | - |
| JRC42_RS22425 (4564648) | 4564648..4564926 | - | 279 | WP_001296612.1 | hypothetical protein | - |
| JRC42_RS22430 (4564988) | 4564988..4565200 | - | 213 | WP_000197774.1 | hypothetical protein | - |
| JRC42_RS22435 (4565285) | 4565285..4565575 | - | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
| JRC42_RS22440 (4565576) | 4565576..4565887 | - | 312 | WP_000897302.1 | hypothetical protein | Toxin |
| JRC42_RS22445 (4566116) | 4566116..4567024 | + | 909 | WP_204619763.1 | alpha/beta hydrolase | - |
| JRC42_RS22450 (4567088) | 4567088..4568029 | - | 942 | WP_204620272.1 | bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase | - |
| JRC42_RS22455 (4568074) | 4568074..4568511 | - | 438 | WP_000560977.1 | D-aminoacyl-tRNA deacylase | - |
| JRC42_RS22460 (4568508) | 4568508..4569380 | - | 873 | WP_204619764.1 | virulence factor BrkB family protein | - |
| JRC42_RS22465 (4569374) | 4569374..4569973 | - | 600 | WP_204619765.1 | glucose-1-phosphatase | - |
| JRC42_RS22470 (4570072) | 4570072..4570512 | - | 441 | Protein_4436 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4541012..4565887 | 24875 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T193628 WP_000897302.1 NZ_CP070281:c4565887-4565576 [Escherichia albertii]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T193628 NZ_CP093042:c854360-854052 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT193628 WP_000356397.1 NZ_CP070281:c4565575-4565285 [Escherichia albertii]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT193628 NZ_CP093042:c854071-853787 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|