Detailed information of TA system TA193623

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-sokC/SymE(toxin)
• Location: 4025666..4026078
• Replicon: chromosome
• Accession: NZ_CP070281
• Organism: Escherichia albertii strain Sample 170

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: JRC42_RS19885
• Protein ID: WP_204677743.1
• Coordinates: 4025737..4026078 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4025666..4025742 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC42_RS19875 (4022262)	4022262..4023731	+	1470	WP_149450978.1	type I restriction-modification system subunit M	-
JRC42_RS19880 (4023731)	4023731..4025515	+	1785	WP_208629286.1	restriction endonuclease subunit S	-
- (4025666)	4025666..4025742	-	77	NuclAT_6	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_6	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_6	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_6	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_7	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_7	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_7	-	Antitoxin
- (4025666)	4025666..4025742	-	77	NuclAT_7	-	Antitoxin
JRC42_RS19885 (4025737)	4025737..4026078	+	342	WP_204677743.1	endoribonuclease SymE	Toxin
JRC42_RS19890 (4026240)	4026240..4027618	+	1379	Protein_3934	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JRC42_RS19895 (4027618)	4027618..4028664	+	1047	WP_204619684.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
JRC42_RS19900 (4028720)	4028720..4029798	-	1079	Protein_3936	DUF1998 domain-containing protein	-
JRC42_RS19905 (4030113)	4030113..4031045	-	933	WP_204619685.1	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4018654..4042056	23402

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12354.18 Da
• Isoelectric Point: 7.8219

>T193623 WP_204677743.1 NZ_CP070281:4025737-4026078 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTTQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T193623 NZ_CP093041:c843605-843297 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT193623 NZ_CP070281:c4025742-4025666 [Escherichia albertii]
AGTCATGATTACTATTCCTTAGAAATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin