Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2375903..2376465 Replicon chromosome
Accession NZ_CP070281
Organism Escherichia albertii strain Sample 170

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JRC42_RS11665 Protein ID WP_059277893.1
Coordinates 2375903..2376181 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag JRC42_RS11670 Protein ID WP_021528209.1
Coordinates 2376181..2376465 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC42_RS11645 (2371892) 2371892..2372323 - 432 WP_000152289.1 peroxiredoxin OsmC -
JRC42_RS11650 (2372581) 2372581..2372718 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
JRC42_RS11655 (2372875) 2372875..2374572 + 1698 WP_059259313.1 malate dehydrogenase -
JRC42_RS11660 (2374707) 2374707..2375717 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
JRC42_RS11665 (2375903) 2375903..2376181 + 279 WP_059277893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JRC42_RS11670 (2376181) 2376181..2376465 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
JRC42_RS11675 (2376470) 2376470..2376946 - 477 WP_059225294.1 NUDIX domain-containing protein -
JRC42_RS11680 (2377019) 2377019..2377672 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
JRC42_RS11685 (2377665) 2377665..2378549 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.12 Da        Isoelectric Point: 8.0733

>T193618 WP_059277893.1 NZ_CP070281:2375903-2376181 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCIADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GNAYILDYEDYH

Download         Length: 279 bp

>T193618 NZ_CP093040:c1662947-1662270 [Bartonella krasnovii]
GTGGAGAAGTATAAAGGGAGTGGTGATCCTTATACTGATCCTAAAACTGGTGTACTATATAATCGGTTTGGTATTAAAGA
CAAAGCCACATTGGATCGTGTAGAATCTACTTTCGCTTATGTAAGGTCTTTTGAACTTATGCTTGCTGCTATTCGTGGTA
AGTTTGATCTCAGCTACATGAAAGAGATCCATAGAAAGCTGTTTGGTGACATATATGAATGGGCGGGAGAGGTTCGTTTA
GTGGATATTGCCAAAGGCAATAGTATGTTTGCGAGTTATCATCAGATTGAAAGTTATGCCCCGAAGATTACGCAACAGCT
TGCAAAAGAACAGTATCTGCGTGGTCTTAATATGGATGAATTTAGCCAAAGGGCTGGATATTACATGGGAGAGTTGAATG
CGTTGCATCCCTTTCGAGAGGGAAATGGGCGCACGTTGCGTGAATTTATGGGGCAACTTGCTCGTGAAGCTGGTTATCAT
ATCAGCTGGAAGGGGATCGAGAAACAAGAAATGATAGAGGCATCTATTGCGGCCCATTTTGGGAAGTCTGAACACTTGTC
TGTACTCATCCATAAGAACCTTATCAAATTTACAGAAAATGAAAGAGATGATGTTACCCATCTTGGGGAAAAAATTTCCT
CTTATATTGAGATTAATAAAGAATTATACGAAGGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT193618 WP_021528209.1 NZ_CP070281:2376181-2376465 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT193618 NZ_CP093040:c1663122-1662934 [Bartonella krasnovii]
ATGTTGAGTGAAGACGAAATTAAACGACGTCGCTTTGCTGCTAAAAATGCATTAGCAAGCCAACGGTTAGAGGGATTGGA
ACCCGATCCAAAAGTCGTTGAGCAAATGGAGCGTGTTATTATTGGAGAACTTGAAACAAGTGACGTAATTAGAGATTATA
TGGAGCGGGTAAAACGTGGAGAAGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References