Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1018555..1018801 Replicon chromosome
Accession NZ_CP070281
Organism Escherichia albertii strain Sample 170

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag JRC42_RS04855 Protein ID WP_000956458.1
Coordinates 1018649..1018801 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1018555..1018607 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC42_RS04840 1013956..1015758 + 1803 WP_204677920.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
JRC42_RS04845 1015758..1017470 + 1713 WP_059273794.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
JRC42_RS04850 1017650..1018384 + 735 WP_137646802.1 phosphoadenosine phosphosulfate reductase -
- 1018555..1018607 - 53 - - Antitoxin
JRC42_RS04855 1018649..1018801 + 153 WP_000956458.1 Hok/Gef family protein Toxin
JRC42_RS04860 1018927..1019964 - 1038 WP_059268554.1 alkaline phosphatase isozyme conversion aminopeptidase -
JRC42_RS04865 1020218..1021126 + 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
JRC42_RS04870 1021128..1022555 + 1428 WP_141109490.1 sulfate adenylyltransferase subunit CysN -
JRC42_RS04875 1022555..1023160 + 606 WP_204620204.1 adenylyl-sulfate kinase -
JRC42_RS04880 1023210..1023533 + 324 WP_001246114.1 DUF3561 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T193607 WP_000956458.1 NZ_CP070281:1018649-1018801 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T193607 NZ_CP093038:c971750-971466 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA

Antitoxin


Download         Length: 53 bp

>AT193607 NZ_CP070281:c1018607-1018555 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References