Detailed information of TA system TA193601

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 158311..158568
• Replicon: chromosome
• Accession: NZ_CP070281
• Organism: Escherichia albertii strain Sample 170

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: JRC42_RS00710
• Protein ID: WP_001135738.1
• Coordinates: 158416..158568 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	158311..158359 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC42_RS00690	153541..154536	-	996	WP_059259085.1	acyltransferase	-
JRC42_RS00695	154710..155009	+	300	WP_204619831.1	YsaB family lipoprotein	-
JRC42_RS00700	155104..156015	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
JRC42_RS00705	156025..158094	+	2070	WP_204677869.1	glycine--tRNA ligase subunit beta	-
-	158311..158359	-	49	-	-	Antitoxin
JRC42_RS00710	158416..158568	+	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
JRC42_RS24980	158545..158616	-	72	WP_212734940.1	hypothetical protein	-
JRC42_RS00715	158756..158968	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
JRC42_RS00720	159251..159541	-	291	WP_000455794.1	HTH-type transcriptional regulator	-
JRC42_RS00725	159964..160674	+	711	WP_002460072.1	DUF3053 domain-containing protein	-
JRC42_RS00730	160727..161701	-	975	WP_204619832.1	glyoxylate/hydroxypyruvate reductase GhrB	-
JRC42_RS00735	161805..162464	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T193601 WP_001135738.1 NZ_CP070281:158416-158568 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T193601 NZ_CP093036:c1027363-1027031 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin

Nucleotide

• Length: 49 bp

>AT193601 NZ_CP070281:c158359-158311 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin