Detailed information of TA system TA193591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2420649..2421287
• Replicon: chromosome
• Accession: NZ_CP070232
• Organism: Escherichia coli strain 10R

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: JTF63_RS11695
• Protein ID: WP_001447010.1
• Coordinates: 2421111..2421287 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JTF63_RS11690
• Protein ID: WP_001270286.1
• Coordinates: 2420649..2421065 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTF63_RS11670	2415801..2416742	-	942	WP_001251304.1	ABC transporter permease	-
JTF63_RS11675	2416743..2417756	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
JTF63_RS11680	2417774..2418919	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
JTF63_RS11685	2419164..2420570	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
JTF63_RS11690	2420649..2421065	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
JTF63_RS11695	2421111..2421287	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
JTF63_RS11700	2421509..2421739	+	231	WP_000494244.1	YncJ family protein	-
JTF63_RS11705	2421831..2423792	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
JTF63_RS11710	2423865..2424401	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
JTF63_RS11715	2424454..2425668	+	1215	WP_001326689.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP020543 Escherichia coli C IS/Tn TA075073 2433298..2434446 0.008	flank	IS/Tn	-	-	2425708..2426856	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T193591 WP_001447010.1 NZ_CP070232:c2421287-2421111 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T193591 NZ_CP093034:c795119-794811 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT193591 WP_001270286.1 NZ_CP070232:c2421065-2420649 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT193591 NZ_CP093034:c794830-794546 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8