Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2420649..2421287 Replicon chromosome
Accession NZ_CP070232
Organism Escherichia coli strain 10R

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag JTF63_RS11695 Protein ID WP_001447010.1
Coordinates 2421111..2421287 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JTF63_RS11690 Protein ID WP_001270286.1
Coordinates 2420649..2421065 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTF63_RS11670 2415801..2416742 - 942 WP_001251304.1 ABC transporter permease -
JTF63_RS11675 2416743..2417756 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JTF63_RS11680 2417774..2418919 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JTF63_RS11685 2419164..2420570 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JTF63_RS11690 2420649..2421065 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JTF63_RS11695 2421111..2421287 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JTF63_RS11700 2421509..2421739 + 231 WP_000494244.1 YncJ family protein -
JTF63_RS11705 2421831..2423792 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JTF63_RS11710 2423865..2424401 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JTF63_RS11715 2424454..2425668 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2425708..2426856 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T193591 WP_001447010.1 NZ_CP070232:c2421287-2421111 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T193591 NZ_CP093034:c795119-794811 [Bartonella krasnovii]
ATGATACTCATTCATAAAACAATAGAATTTGATACTTGGCTTAAGAAACTTAAAGATAAAAGCGTTAAGGCTATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTCGGTGATGTTAAATTCTTTCATGGCATAGGGGAATTACGTATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGCGGTGGAGATAAATCAACG
CAGCAAAGAGATATTGAACAAGCGTTAAAATTAAAAGAGGAGTACAGTGATGAAAATAACCCCATTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT193591 WP_001270286.1 NZ_CP070232:c2421065-2420649 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT193591 NZ_CP093034:c794830-794546 [Bartonella krasnovii]
ATGAAAATAACCCCATTTAAACCAGAAGAATATCTTAAAGACATTGAGTCACAGAAAATTTTTCTCAATGAAGCCCTTAA
AACCGGTGATGCCGCCCACATTGCCGATGCTCTTGGTATCGTTGCTCGTGCCCAAAATATGAGTGCCTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATACCGTTCCTTAAGTAAAACGGGTGACCCAAAGCTTTCTACCTTAGTCGCTGTATTA
TCTGCCCTTAATTTACAACTCTCTGTACAATCTTCTACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References