Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 92348..92774 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP070230 | ||
| Organism | Escherichia coli strain EC12 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | JTC67_RS25370 | Protein ID | WP_001372321.1 |
| Coordinates | 92348..92473 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 92550..92774 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTC67_RS25325 (87414) | 87414..87641 | - | 228 | WP_000589558.1 | conjugal transfer relaxosome protein TraY | - |
| JTC67_RS25330 (87761) | 87761..88408 | - | 648 | WP_074464494.1 | transcriptional regulator TraJ family protein | - |
| JTC67_RS25335 (88600) | 88600..88983 | - | 384 | WP_001151530.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| JTC67_RS25340 (89259) | 89259..89906 | + | 648 | WP_139118357.1 | transglycosylase SLT domain-containing protein | - |
| JTC67_RS25345 (90201) | 90201..91021 | - | 821 | Protein_112 | DUF945 domain-containing protein | - |
| JTC67_RS25350 (91140) | 91140..91426 | - | 287 | Protein_113 | hypothetical protein | - |
| JTC67_RS25355 (91451) | 91451..91657 | - | 207 | WP_062897188.1 | hypothetical protein | - |
| JTC67_RS25360 (91727) | 91727..91900 | + | 174 | Protein_115 | hypothetical protein | - |
| JTC67_RS25365 (91898) | 91898..92128 | - | 231 | WP_073976915.1 | hypothetical protein | - |
| JTC67_RS25370 (92348) | 92348..92473 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| JTC67_RS25375 (92415) | 92415..92564 | - | 150 | Protein_118 | plasmid maintenance protein Mok | - |
| - (92550) | 92550..92774 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92550) | 92550..92774 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92550) | 92550..92774 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92550) | 92550..92774 | - | 225 | NuclAT_0 | - | Antitoxin |
| JTC67_RS25380 (92586) | 92586..92774 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| JTC67_RS25385 (92743) | 92743..93505 | - | 763 | Protein_120 | plasmid SOS inhibition protein A | - |
| JTC67_RS25390 (93502) | 93502..93936 | - | 435 | WP_062860170.1 | conjugation system SOS inhibitor PsiB | - |
| JTC67_RS25395 (93991) | 93991..95948 | - | 1958 | Protein_122 | ParB/RepB/Spo0J family partition protein | - |
| JTC67_RS25400 (96013) | 96013..96246 | - | 234 | WP_000006030.1 | DUF905 family protein | - |
| JTC67_RS25405 (96308) | 96308..96847 | - | 540 | WP_009426937.1 | single-stranded DNA-binding protein | - |
| JTC67_RS25410 (96873) | 96873..97079 | - | 207 | WP_000547971.1 | hypothetical protein | - |
| JTC67_RS25415 (97320) | 97320..97565 | - | 246 | WP_071602007.1 | hypothetical protein | - |
| JTC67_RS25420 (97490) | 97490..97720 | - | 231 | WP_225876888.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA | 1..163194 | 163194 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T193569 WP_001372321.1 NZ_CP070230:c92473-92348 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T193569 NZ_CP093030:3840278-3840856 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 225 bp
>AT193569 NZ_CP070230:c92774-92550 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
