Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 498426..499225 Replicon chromosome
Accession NZ_CP070170
Organism Escherichia coli strain FDAARGOS_1284

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag I6K14_RS02415 Protein ID WP_087598199.1
Coordinates 498426..498890 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag I6K14_RS02420 Protein ID WP_087598198.1
Coordinates 498890..499225 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K14_RS02385 (493427) 493427..493861 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
I6K14_RS02390 (493879) 493879..494757 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
I6K14_RS02395 (494747) 494747..495526 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
I6K14_RS02400 (495537) 495537..496010 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6K14_RS02405 (496033) 496033..497313 - 1281 WP_052925113.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6K14_RS02410 (497562) 497562..498371 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
I6K14_RS02415 (498426) 498426..498890 - 465 WP_087598199.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6K14_RS02420 (498890) 498890..499225 - 336 WP_087598198.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6K14_RS02425 (499374) 499374..500945 - 1572 WP_001273940.1 galactarate dehydratase -
I6K14_RS02430 (501320) 501320..502654 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
I6K14_RS02435 (502670) 502670..503440 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17811.16 Da        Isoelectric Point: 9.4947

>T193459 WP_087598199.1 NZ_CP070170:c498890-498426 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDAFVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T193459 NZ_CP092983:c386306-386121 [Leptospira interrogans]
ATGAAAGTCAAAGAGATCATCAAAATTTTAGAGGATGACGGTTGGTATTTAGTGGATCAAAGAGGAAGTCACAGACAGTT
TAAACATACCTTAAAATCTGGGAGAGTAACTGTAGCGGGAAAGTCGAGTATGGATTTACCTCCTGGAACCTTGAATAGTA
TCTTAAAACAATCCGGTCTAAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12303.88 Da        Isoelectric Point: 4.5392

>AT193459 WP_087598198.1 NZ_CP070170:c499225-498890 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFLCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT193459 NZ_CP092983:c386104-385901 [Leptospira interrogans]
ATGGAATATCCAGTAATGATTGAAAAAAATTCGACCGGTTATGGAGCGTATGTTCCGGATTTACCTGGCTGTGTTGCAGT
TGGAGAAACGGAAGCGGAAGTAACTCGGTTAATCAAGGAAGCGATTGAGTTTCATTTAGAAGGTATGCGTAAAGATGGGG
AGCGGGTTCCTAATCCTTCCAAGGTAATGTTAATTGCGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References