Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4878065..4878667 | Replicon | chromosome |
Accession | NZ_CP070148 | ||
Organism | Escherichia coli strain FDAARGOS_1297 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | I6K27_RS23435 | Protein ID | WP_000897302.1 |
Coordinates | 4878065..4878376 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | I6K27_RS23440 | Protein ID | WP_000356397.1 |
Coordinates | 4878377..4878667 (+) | Length | 97 a.a. |
Genomic Context
Location: 4873979..4874578 (600 bp)
Type: Others
Protein ID: WP_001314324.1
Type: Others
Protein ID: WP_001314324.1
Location: 4874572..4875444 (873 bp)
Type: Others
Protein ID: WP_000920762.1
Type: Others
Protein ID: WP_000920762.1
Location: 4875441..4875878 (438 bp)
Type: Others
Protein ID: WP_000560983.1
Type: Others
Protein ID: WP_000560983.1
Location: 4875923..4876864 (942 bp)
Type: Others
Protein ID: WP_001297068.1
Type: Others
Protein ID: WP_001297068.1
Location: 4878065..4878376 (312 bp)
Type: Toxin
Protein ID: WP_000897302.1
Type: Toxin
Protein ID: WP_000897302.1
Location: 4878377..4878667 (291 bp)
Type: Antitoxin
Protein ID: WP_000356397.1
Type: Antitoxin
Protein ID: WP_000356397.1
Location: 4879026..4879304 (279 bp)
Type: Others
Protein ID: WP_001296612.1
Type: Others
Protein ID: WP_001296612.1
Location: 4879700..4879918 (219 bp)
Type: Others
Protein ID: WP_001314326.1
Type: Others
Protein ID: WP_001314326.1
Location: 4876928..4877836 (909 bp)
Type: Others
Protein ID: WP_001331553.1
Type: Others
Protein ID: WP_001331553.1
Location: 4880134..4881063 (930 bp)
Type: Others
Protein ID: WP_000027720.1
Type: Others
Protein ID: WP_000027720.1
Location: 4881060..4881695 (636 bp)
Type: Others
Protein ID: WP_000829013.1
Type: Others
Protein ID: WP_000829013.1
Location: 4881692..4882594 (903 bp)
Type: Others
Protein ID: WP_000331377.1
Type: Others
Protein ID: WP_000331377.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K27_RS23410 (4873979) | 4873979..4874578 | + | 600 | WP_001314324.1 | glucose-1-phosphatase | - |
I6K27_RS23415 (4874572) | 4874572..4875444 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
I6K27_RS23420 (4875441) | 4875441..4875878 | + | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
I6K27_RS23425 (4875923) | 4875923..4876864 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
I6K27_RS23430 (4876928) | 4876928..4877836 | - | 909 | WP_001331553.1 | alpha/beta hydrolase | - |
I6K27_RS23435 (4878065) | 4878065..4878376 | + | 312 | WP_000897302.1 | hypothetical protein | Toxin |
I6K27_RS23440 (4878377) | 4878377..4878667 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
I6K27_RS23445 (4879026) | 4879026..4879304 | + | 279 | WP_001296612.1 | hypothetical protein | - |
I6K27_RS23450 (4879700) | 4879700..4879918 | + | 219 | WP_001314326.1 | CopG family transcriptional regulator | - |
I6K27_RS23455 (4880134) | 4880134..4881063 | - | 930 | WP_000027720.1 | formate dehydrogenase accessory protein FdhE | - |
I6K27_RS23460 (4881060) | 4881060..4881695 | - | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
I6K27_RS23465 (4881692) | 4881692..4882594 | - | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T193333 WP_000897302.1 NZ_CP070148:4878065-4878376 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T193333 NZ_CP092860:c4904781-4904407 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT193333 WP_000356397.1 NZ_CP070148:4878377-4878667 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT193333 NZ_CP092860:c4905023-4904781 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | S1P416 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |