Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4878065..4878667 Replicon chromosome
Accession NZ_CP070148
Organism Escherichia coli strain FDAARGOS_1297

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag I6K27_RS23435 Protein ID WP_000897302.1
Coordinates 4878065..4878376 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6K27_RS23440 Protein ID WP_000356397.1
Coordinates 4878377..4878667 (+) Length 97 a.a.

Genomic Context


I6K27_RS23410I6K27_RS23415I6K27_RS23420I6K27_RS23425I6K27_RS23435I6K27_RS23440I6K27_RS23445I6K27_RS23450I6K27_RS23430I6K27_RS23455I6K27_RS23460I6K27_RS23465
Location: 4873979..4874578 (600 bp)
Type: Others
Protein ID: WP_001314324.1
Location: 4874572..4875444 (873 bp)
Type: Others
Protein ID: WP_000920762.1
Location: 4875441..4875878 (438 bp)
Type: Others
Protein ID: WP_000560983.1
Location: 4875923..4876864 (942 bp)
Type: Others
Protein ID: WP_001297068.1
Location: 4878065..4878376 (312 bp)
Type: Toxin
Protein ID: WP_000897302.1
Location: 4878377..4878667 (291 bp)
Type: Antitoxin
Protein ID: WP_000356397.1
Location: 4879026..4879304 (279 bp)
Type: Others
Protein ID: WP_001296612.1
Location: 4879700..4879918 (219 bp)
Type: Others
Protein ID: WP_001314326.1
Location: 4876928..4877836 (909 bp)
Type: Others
Protein ID: WP_001331553.1
Location: 4880134..4881063 (930 bp)
Type: Others
Protein ID: WP_000027720.1
Location: 4881060..4881695 (636 bp)
Type: Others
Protein ID: WP_000829013.1
Location: 4881692..4882594 (903 bp)
Type: Others
Protein ID: WP_000331377.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6K27_RS23410 (4873979)4873979..4874578+600WP_001314324.1glucose-1-phosphatase-
I6K27_RS23415 (4874572)4874572..4875444+873WP_000920762.1virulence factor BrkB family protein-
I6K27_RS23420 (4875441)4875441..4875878+438WP_000560983.1D-aminoacyl-tRNA deacylase-
I6K27_RS23425 (4875923)4875923..4876864+942WP_001297068.1fatty acid biosynthesis protein FabY-
I6K27_RS23430 (4876928)4876928..4877836-909WP_001331553.1alpha/beta hydrolase-
I6K27_RS23435 (4878065)4878065..4878376+312WP_000897302.1hypothetical proteinToxin
I6K27_RS23440 (4878377)4878377..4878667+291WP_000356397.1NadS family proteinAntitoxin
I6K27_RS23445 (4879026)4879026..4879304+279WP_001296612.1hypothetical protein-
I6K27_RS23450 (4879700)4879700..4879918+219WP_001314326.1CopG family transcriptional regulator-
I6K27_RS23455 (4880134)4880134..4881063-930WP_000027720.1formate dehydrogenase accessory protein FdhE-
I6K27_RS23460 (4881060)4881060..4881695-636WP_000829013.1formate dehydrogenase cytochrome b556 subunit-
I6K27_RS23465 (4881692)4881692..4882594-903WP_000331377.1formate dehydrogenase O subunit beta-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T193333 WP_000897302.1 NZ_CP070148:4878065-4878376 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T193333 NZ_CP092860:c4904781-4904407 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT193333 WP_000356397.1 NZ_CP070148:4878377-4878667 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT193333 NZ_CP092860:c4905023-4904781 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBS1P416


Antitoxin

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Source
ID
Structure
No matching records found

References