Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2786535..2787185 Replicon chromosome
Accession NZ_CP070144
Organism Klebsiella oxytoca strain FDAARGOS_1331

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6K61_RS12930 Protein ID WP_049128706.1
Coordinates 2786844..2787185 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6K61_RS12925 Protein ID WP_017145203.1
Coordinates 2786535..2786834 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K61_RS12905 2782421..2783140 - 720 WP_004107085.1 phosphonate utilization transcriptional regulator PhnR -
I6K61_RS12910 2783281..2784384 + 1104 WP_049593719.1 2-aminoethylphosphonate--pyruvate transaminase -
I6K61_RS12915 2784394..2785203 + 810 WP_032729158.1 phosphonoacetaldehyde hydrolase -
I6K61_RS12920 2785235..2786416 - 1182 WP_017145204.1 purine ribonucleoside efflux pump NepI -
I6K61_RS12925 2786535..2786834 - 300 WP_017145203.1 helix-turn-helix transcriptional regulator Antitoxin
I6K61_RS12930 2786844..2787185 - 342 WP_049128706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K61_RS12935 2787437..2787889 - 453 WP_004116616.1 DUF1198 domain-containing protein -
I6K61_RS12940 2788067..2789458 - 1392 WP_004107098.1 hexose-6-phosphate:phosphate antiporter -
I6K61_RS12945 2789604..2790923 - 1320 WP_004107101.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13064.90 Da        Isoelectric Point: 5.7456

>T193297 WP_049128706.1 NZ_CP070144:c2787185-2786844 [Klebsiella oxytoca]
MWNVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFVFDPSRRGI
LLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T193297 NZ_CP092844:c1323686-1323390 [Burkholderia ambifaria]
ATGGAAAAGAGAACGCCTCACTGCAAGCTGTCCCGGGTCAAGGCACTCGTCGAGGCCGGCAACGTTCGGATGACGACGAG
TGCGGTATTGGGCGCCCGGCAACTGGGTTTTACGCCAAACGAGGCAATCGGTATCGTAATGTCGCTGGACACCGCGGATT
TCTACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTATTGGCGCCGCACGGTGAACGGCGACGTG
TATCTGAAACTGACCGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10874.80 Da        Isoelectric Point: 10.0948

>AT193297 WP_017145203.1 NZ_CP070144:c2786834-2786535 [Klebsiella oxytoca]
MATLKELMAKQSPESQARIAEKVEAMRQVIALSMLREELNLSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPGGKRIAFHL

Download         Length: 300 bp

>AT193297 NZ_CP092844:c1323387-1322986 [Burkholderia ambifaria]
ATGAAGTGTCCTGCCTGCGGCGCCGCGAAGCTGATTCGGGATACACGAGACATTCCGTACACGTACAAGGGTCGCTCGAC
CGTCGTTCGCGATATAACCGGCGACTTCTGTCCGGCCTGCGGCGAGTCGGTGCTCGATATCGACGAGGCAACCCGGCTCG
GTGAAGCGATCGGCGAGTTCAACAAACAAGTGAATTCGACCATCGTCGACCCGAGGTTCATCGCGAAGGTGCGCAAGAAG
CTGATGCTGGATCAACGCGAGGCGGCCGAGATCTTCGGTGGCGGCGTCAATGCCTTCTCTCGCTACGAAACCGGCAAGAC
GAACCCCCCGCTTGCCCTGGTGAAGCTGCTCAAGATTCTGGATCGTCATCCGGATCTGCTCGCGGAAGTGCGCGCAGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References