Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13982..14628 Replicon plasmid unnamed4
Accession NZ_CP070136
Organism Escherichia coli strain FDAARGOS_1281

Toxin (Protein)


Gene name higB Uniprot ID A0A3P1YQM6
Locus tag I6K11_RS26840 Protein ID WP_025667955.1
Coordinates 14281..14628 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1V3UZT0
Locus tag I6K11_RS26835 Protein ID WP_001259436.1
Coordinates 13982..14281 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K11_RS26795 (I6K11_26835) 9104..9352 + 249 WP_000730008.1 hypothetical protein -
I6K11_RS26800 (I6K11_26840) 9415..9564 + 150 WP_000003577.1 hypothetical protein -
I6K11_RS26805 (I6K11_26845) 10193..10348 + 156 Protein_20 ash family protein -
I6K11_RS26810 (I6K11_26850) 10462..10653 + 192 WP_097301671.1 hypothetical protein -
I6K11_RS27820 10650..11000 + 351 Protein_22 ORF6N domain-containing protein -
I6K11_RS27825 11169..11795 + 627 WP_236922098.1 Rha family transcriptional regulator -
I6K11_RS26820 (I6K11_26860) 11830..12465 - 636 WP_000525634.1 hypothetical protein -
I6K11_RS26825 (I6K11_26865) 13101..13373 - 273 WP_000148348.1 helix-turn-helix domain-containing protein -
I6K11_RS26830 (I6K11_26870) 13437..13817 - 381 WP_000061763.1 hypothetical protein -
I6K11_RS26835 (I6K11_26875) 13982..14281 - 300 WP_001259436.1 XRE family transcriptional regulator Antitoxin
I6K11_RS26840 (I6K11_26880) 14281..14628 - 348 WP_025667955.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K11_RS26845 (I6K11_26885) 14873..15136 - 264 WP_000424604.1 hypothetical protein -
I6K11_RS26850 (I6K11_26890) 15160..15447 - 288 WP_000356589.1 hypothetical protein -
I6K11_RS26855 (I6K11_26895) 16091..17071 - 981 WP_241336524.1 plasmid replication initiator RepA -
I6K11_RS26860 (I6K11_26900) 17279..17806 - 528 WP_032152674.1 tail fiber assembly protein -
I6K11_RS26865 (I6K11_26905) 17808..18848 - 1041 WP_251296402.1 phage tail protein -
I6K11_RS26870 (I6K11_26910) 18858..19136 - 279 WP_032152803.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48183 48183


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13530.50 Da        Isoelectric Point: 9.3634

>T193293 WP_025667955.1 NZ_CP070136:c14628-14281 [Escherichia coli]
MWTVLFSQRFDDWLNEQEDALQEKVLADLKNLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYKKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

>T193293 NZ_CP092844:c714610-714029 [Burkholderia ambifaria]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGACGGGCCGCCGCGAAAGCACGGCCGAGCACAGCTGGCGACTGTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGATGTCGACACGACGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCT
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCACGAACGCGACGACCTGCTGACGCTGACGGCCGGGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCACCGGAAGCGCGCGCGGCGAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGTGCGATCCGCGCGATCGTCGACGCGGACACCCAACGCAGGATCGA
CGCACGCGGCGACGGCGCGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11074.92 Da        Isoelectric Point: 5.2090

>AT193293 WP_001259436.1 NZ_CP070136:c14281-13982 [Escherichia coli]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRIAFNI

Download         Length: 300 bp

>AT193293 NZ_CP092844:c715276-714719 [Burkholderia ambifaria]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AACGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGATTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCACACGCACCGTTTGCTCGCCTGCTCGCCGTCGCGCGCGGCCGAGTTCTC
GCGGCCGCTGCCGACGTTGCTCGGTACCTCGCTGTGGCGCTATGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCGGGGCCGCCCAGCGTCGAATTCGCGACCGGCGCCAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCACCTGCCGGTGGACGCGCATGACGCTGTCGGATGGCTCCGCCGCGCGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P1YQM6

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3UZT0

References