Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2031523..2032216 Replicon chromosome
Accession NZ_CP070134
Organism Escherichia coli strain FDAARGOS_1281

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K11_RS10800 Protein ID WP_000415584.1
Coordinates 2031920..2032216 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K11_RS10795 Protein ID WP_000650107.1
Coordinates 2031523..2031918 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K11_RS10785 (2027387) 2027387..2029645 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
I6K11_RS10790 (2029783) 2029783..2031390 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
I6K11_RS10795 (2031523) 2031523..2031918 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K11_RS10800 (2031920) 2031920..2032216 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K11_RS10805 (2032421) 2032421..2032903 - 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K11_RS10810 (2032956) 2032956..2033348 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K11_RS10815 (2033500) 2033500..2034159 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
I6K11_RS10820 (2034156) 2034156..2035505 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K11_RS10825 (2035551) 2035551..2035883 - 333 WP_023149630.1 DUF2645 family protein -
I6K11_RS10830 (2036202) 2036202..2036783 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I6K11_RS10835 (2036814) 2036814..2037128 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T193278 WP_000415584.1 NZ_CP070134:c2032216-2031920 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T193278 NZ_CP092828:c2960047-2959706 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT193278 WP_000650107.1 NZ_CP070134:c2031918-2031523 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT193278 NZ_CP092828:c2959696-2959397 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AGCCCACCATTGCTAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References