Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 37777..38148 | Replicon | chromosome |
| Accession | NZ_CP070134 | ||
| Organism | Escherichia coli strain FDAARGOS_1281 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | I6K11_RS01220 | Protein ID | WP_001443846.1 |
| Coordinates | 37999..38148 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 37777..37955 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K11_RS27840 (33529) | 33529..33702 | + | 174 | WP_001296046.1 | protein YnaL | - |
| I6K11_RS01195 (33732) | 33732..35105 | + | 1374 | WP_000123748.1 | ATP-dependent RNA helicase DbpA | - |
| I6K11_RS01200 (35234) | 35234..36169 | - | 936 | WP_001523172.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| I6K11_RS01205 (36221) | 36221..37456 | - | 1236 | WP_000040839.1 | site-specific integrase | - |
| I6K11_RS01210 (37458) | 37458..37673 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (37777) | 37777..37955 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (37777) | 37777..37955 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (37777) | 37777..37955 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (37777) | 37777..37955 | + | 179 | NuclAT_0 | - | Antitoxin |
| I6K11_RS01215 (37773) | 37773..37961 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| I6K11_RS01220 (37999) | 37999..38148 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| I6K11_RS01225 (38204) | 38204..39013 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| I6K11_RS01230 (39006) | 39006..41606 | - | 2601 | WP_000105140.1 | exodeoxyribonuclease VIII | - |
| I6K11_RS01235 (41708) | 41708..41983 | - | 276 | WP_001344816.1 | hypothetical protein | - |
| I6K11_RS01240 (42058) | 42058..42228 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| I6K11_RS01245 (42228) | 42228..42449 | - | 222 | WP_000560223.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 36221..89148 | 52927 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T193258 WP_001443846.1 NZ_CP070134:c38148-37999 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T193258 NZ_CP092825:c882057-881869 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 179 bp
>AT193258 NZ_CP070134:37777-37955 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
