Detailed information of TA system TA193248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4925690..4925948
• Replicon: chromosome
• Accession: NZ_CP070124
• Organism: Escherichia coli strain FDAARGOS_1292

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6K22_RS23635
• Protein ID: WP_000809168.1
• Coordinates: 4925796..4925948 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4925690..4925747 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K22_RS23620	4921522..4922781	-	1260	WP_000494924.1	hypothetical protein	-
I6K22_RS23625	4922910..4924403	-	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
I6K22_RS23630	4924423..4925184	-	762	WP_001274823.1	outer membrane protein OmpK	-
-	4925690..4925747	-	58	-	-	Antitoxin
I6K22_RS23635	4925796..4925948	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
I6K22_RS23640	4926053..4927183	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6K22_RS23645	4927272..4929188	-	1917	WP_000516135.1	molecular chaperone DnaK	-
I6K22_RS23650	4929560..4929964	+	405	WP_000843687.1	DUF2541 family protein	-
I6K22_RS23655	4929990..4930703	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T193248 WP_000809168.1 NZ_CP070124:4925796-4925948 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T193248 NZ_CP092794:c41044-40733 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT193248 NZ_CP070124:c4925747-4925690 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin