Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 693292..693550 Replicon chromosome
Accession NZ_CP070115
Organism Escherichia coli strain FDAARGOS_1298

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6K28_RS03350 Protein ID WP_000809168.1
Coordinates 693398..693550 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 693292..693349 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K28_RS03335 689124..690383 - 1260 WP_000494924.1 hypothetical protein -
I6K28_RS03340 690512..692005 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
I6K28_RS03345 692025..692786 - 762 WP_001274823.1 outer membrane protein OmpK -
- 693292..693349 - 58 - - Antitoxin
I6K28_RS03350 693398..693550 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
I6K28_RS03355 693655..694785 - 1131 WP_001118464.1 molecular chaperone DnaJ -
I6K28_RS03360 694874..696790 - 1917 WP_000516135.1 molecular chaperone DnaK -
I6K28_RS03365 697162..697566 + 405 WP_000843687.1 DUF2541 family protein -
I6K28_RS03370 697592..698305 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T193201 WP_000809168.1 NZ_CP070115:693398-693550 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T193201 NZ_CP092765:c4773789-4773505 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 58 bp

>AT193201 NZ_CP070115:c693349-693292 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References