Detailed information of TA system TA193190

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3658060..3658282
• Replicon: chromosome
• Accession: NZ_CP070111
• Organism: Escherichia coli strain FDAARGOS_1301

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6K31_RS17515
• Protein ID: WP_001295224.1
• Coordinates: 3658175..3658282 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3658060..3658126 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K31_RS17495	3653932..3654915	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6K31_RS17500	3654912..3655916	+	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6K31_RS17505	3655946..3657217	-	1272	WP_001332306.1	aromatic amino acid transport family protein	-
I6K31_RS17510	3657693..3657800	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3658060..3658126	-	67	-	-	Antitoxin
I6K31_RS17515	3658175..3658282	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6K31_RS17520	3658658..3658765	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K31_RS17525	3658851..3660530	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6K31_RS17530	3660527..3660718	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6K31_RS17535	3660715..3662286	-	1572	WP_001204957.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
I6K31_RS17540	3662559..3662747	+	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T193190 WP_001295224.1 NZ_CP070111:3658175-3658282 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T193190 NZ_CP092759:c4933542-4932625 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT193190 NZ_CP070111:c3658126-3658060 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin