Detailed information of TA system TA193188

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3657578..3657800
• Replicon: chromosome
• Accession: NZ_CP070111
• Organism: Escherichia coli strain FDAARGOS_1301

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: I6K31_RS17510
• Protein ID: WP_000170745.1
• Coordinates: 3657693..3657800 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3657578..3657636 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K31_RS17490	3653019..3653921	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
I6K31_RS17495	3653932..3654915	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6K31_RS17500	3654912..3655916	+	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6K31_RS17505	3655946..3657217	-	1272	WP_001332306.1	aromatic amino acid transport family protein	-
-	3657578..3657636	-	59	-	-	Antitoxin
I6K31_RS17510	3657693..3657800	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6K31_RS17515	3658175..3658282	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K31_RS17520	3658658..3658765	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K31_RS17525	3658851..3660530	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6K31_RS17530	3660527..3660718	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6K31_RS17535	3660715..3662286	-	1572	WP_001204957.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
I6K31_RS17540	3662559..3662747	+	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T193188 WP_000170745.1 NZ_CP070111:3657693-3657800 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T193188 NZ_CP092759:c4672233-4671700 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT193188 NZ_CP070111:c3657636-3657578 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin