193127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3744973..3746561 Replicon chromosome
Accession NZ_CP070103
Organism Escherichia coli strain FDAARGOS_1277

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag I6K07_RS17735 Protein ID WP_001125439.1
Coordinates 3744973..3746295 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6K07_RS17740 Protein ID WP_001301023.1
Coordinates 3746295..3746561 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K07_RS17720 (3742386) 3742386..3743096 - 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -
I6K07_RS17725 (3743457) 3743457..3744020 - 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
I6K07_RS17730 (3744453) 3744453..3744661 - 209 Protein_3490 AraC family transcriptional regulator -
I6K07_RS17735 (3744973) 3744973..3746295 - 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
I6K07_RS17740 (3746295) 3746295..3746561 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimA 3731682..3746561 14879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T193127 WP_001125439.1 NZ_CP070103:c3746295-3744973 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T193127 NZ_CP092713:1039019-1039549 [Aliivibrio fischeri ATCC 7744 = JCM 18803 = DSM 507]
GTGAGTTATTCCAAAACTTTCAAAGAATTGGATAAATCACAGCACGATAGAGCATCATTTGACTGTGGGGAAAAAGAGTT
AAATGATTTTATCCAAACTCAAGCTGCTAAACATATGCAAGCAGGTATCAGCCGCACAATGGTTTTGCCTGCTTCAGTGC
CATTACCAAATCAGAAATATCCAATTTGTTCATTTTATAGTATTGCGCCAAGTTCGATTAGCCGTGATACGTTGCCACAA
GCGATGGCTAAAAAATTACCGCGCTATCCAGTTCCTGTTTTTCTTTTAGCTCAACTTGCAGTTCATAAAGAATTTCATGG
AAGTGGGTTAGGTAAAGTTAGCTTAATCAAAGCTCTCGAATATCTTTGGGAAATTAATTCTCATATGAGAGCTTATGCCA
TTGTTGTTGATTGTTTAACTGAACAAGCAGAGTCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAATGGT
CGTGTAAGAATGTTCATTCCGATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT193127 WP_001301023.1 NZ_CP070103:c3746561-3746295 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT193127 NZ_CP092713:1038753-1039022 [Aliivibrio fischeri ATCC 7744 = JCM 18803 = DSM 507]
ATGGCTACTGTAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCTTCAGCTTTACTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGTCTAATGGACGAAGATTCAACTCAGGTAATTTCTGAGCATGAAAGCATCACTG
TTGAAGCAAATGTATTTGATCAATTCATGATTGCTTGTGACGAGGCTAAGGCTCCGAATAAAGCATTACTTGAAGCCGCT
GCATTTACTAAAAGTGGTGAGTTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References