Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 723297..723990 Replicon chromosome
Accession NZ_CP070103
Organism Escherichia coli strain FDAARGOS_1277

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K07_RS03430 Protein ID WP_000415584.1
Coordinates 723694..723990 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K07_RS03425 Protein ID WP_000650107.1
Coordinates 723297..723692 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K07_RS03415 (719161) 719161..721419 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
I6K07_RS03420 (721557) 721557..723164 - 1608 WP_085004726.1 ABC transporter substrate-binding protein -
I6K07_RS03425 (723297) 723297..723692 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K07_RS03430 (723694) 723694..723990 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K07_RS03435 (724195) 724195..724677 - 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K07_RS03440 (724730) 724730..725122 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K07_RS03445 (725274) 725274..725933 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
I6K07_RS03450 (725930) 725930..727279 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K07_RS03455 (727325) 727325..727657 - 333 WP_000917684.1 DUF2645 family protein -
I6K07_RS03460 (727976) 727976..728557 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I6K07_RS03465 (728588) 728588..728902 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T193108 WP_000415584.1 NZ_CP070103:c723990-723694 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T193108 NZ_CP092702:c2911070-2910735 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT193108 WP_000650107.1 NZ_CP070103:c723692-723297 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT193108 NZ_CP092702:c2911318-2911070 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References