Detailed information of TA system TA193104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1564018..1564673
• Replicon: chromosome
• Accession: NZ_CP070102
• Organism: Bordetella pertussis strain FDAARGOS_1366

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: I6K96_RS07435
• Protein ID: WP_047122780.1
• Coordinates: 1564018..1564269 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: I6K96_RS07440
• Protein ID: WP_003809516.1
• Coordinates: 1564272..1564673 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K96_RS07410	1559179..1560309	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
I6K96_RS07415	1560544..1561125	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
I6K96_RS07420	1561262..1562326	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
I6K96_RS07425	1562411..1562857	-	447	WP_003819827.1	GFA family protein	-
I6K96_RS07430	1563082..1563963	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6K96_RS07435	1564018..1564269	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
I6K96_RS07440	1564272..1564673	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
I6K96_RS07445	1564693..1564929	+	237	WP_010930404.1	membrane protein	-
I6K96_RS07450	1564937..1565416	+	480	WP_010930405.1	disulfide bond formation protein B	-
I6K96_RS07455	1565566..1566081	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6K96_RS07460	1566084..1567274	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6K96_RS07465	1567294..1568331	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
I6K96_RS07470	1568468..1569490	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T193104 WP_047122780.1 NZ_CP070102:1564018-1564269 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T193104 NZ_CP092702:c2089444-2089190 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT193104 WP_003809516.1 NZ_CP070102:1564272-1564673 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT193104 NZ_CP092702:c2089692-2089441 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6