Detailed information of TA system TA193076

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1406652..1407023
• Replicon: chromosome
• Accession: NZ_CP070098
• Organism: Escherichia coli strain FDAARGOS_1370

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: I6L00_RS07295
• Protein ID: WP_001443846.1
• Coordinates: 1406874..1407023 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1406652..1406830 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L00_RS26005 (1402404)	1402404..1402577	+	174	WP_001296046.1	protein YnaL	-
I6L00_RS07270 (1402607)	1402607..1403980	+	1374	WP_000123748.1	ATP-dependent RNA helicase DbpA	-
I6L00_RS07275 (1404109)	1404109..1405044	-	936	WP_001523172.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
I6L00_RS07280 (1405096)	1405096..1406331	-	1236	WP_000040839.1	site-specific integrase	-
I6L00_RS07285 (1406333)	1406333..1406548	-	216	WP_000079604.1	excisionase XisR	-
- (1406652)	1406652..1406830	+	179	NuclAT_0	-	Antitoxin
- (1406652)	1406652..1406830	+	179	NuclAT_0	-	Antitoxin
- (1406652)	1406652..1406830	+	179	NuclAT_0	-	Antitoxin
- (1406652)	1406652..1406830	+	179	NuclAT_0	-	Antitoxin
I6L00_RS07290 (1406648)	1406648..1406836	-	189	WP_001302840.1	DUF1187 family protein	-
I6L00_RS07295 (1406874)	1406874..1407023	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
I6L00_RS07300 (1407079)	1407079..1407888	-	810	WP_000166313.1	recombination protein RecT	-
I6L00_RS07305 (1407881)	1407881..1410481	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
I6L00_RS07310 (1410583)	1410583..1410858	-	276	WP_001344816.1	hypothetical protein	-
I6L00_RS07315 (1410933)	1410933..1411103	-	171	WP_001352098.1	YdaE family protein	-
I6L00_RS07320 (1411103)	1411103..1411324	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1405096..1453435	48339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T193076 WP_001443846.1 NZ_CP070098:c1407023-1406874 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T193076 NZ_CP092689:3216152-3216406 [Gluconobacter frateurii]
ATGAAAGCCAAGCACCGCCGCACTCTGGAACTGATCTTCAAACGCCCCGTGTCGGGCAATGTCGCATGGGGCGATATTGA
AGCTCTGTTCACTGCTCTCGGTGCCGAAATTTCTGAGCGCGAAGGCTCCCGCGTCGGTGTGTTCCTTTTCGGTGAGGTCC
GGGTTTTTCACCGGCCGCATCCGAAGCCGGACACCGACAAAGGGGCCGTTGCTTCCGTTCGGAAATGGCTCGAAGAAAAT
GGAGTGAAGCCATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT193076 NZ_CP070098:1406652-1406830 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin