Detailed information of TA system TA193067

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 55876..56145
• Replicon: plasmid unnamed1
• Accession: NZ_CP070097
• Organism: Escherichia coli strain FDAARGOS_1370

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: I6L00_RS00360
• Protein ID: WP_001372321.1
• Coordinates: 56020..56145 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	55876..55941 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L00_RS00340	51097..53055	+	1959	WP_042045562.1	ParB/RepB/Spo0J family partition protein	-
I6L00_RS00345	53110..53544	+	435	WP_000845949.1	conjugation system SOS inhibitor PsiB	-
I6L00_RS00350	53541..54303	+	763	Protein_58	plasmid SOS inhibition protein A	-
-	54272..54374	+	103	NuclAT_1	-	-
-	54272..54374	+	103	NuclAT_1	-	-
-	54272..54374	+	103	NuclAT_1	-	-
-	54272..54374	+	103	NuclAT_1	-	-
I6L00_RS00355	54420..55789	+	1370	WP_085947770.1	IS3-like element IS150 family transposase	-
-	55816..55943	+	128	NuclAT_0	-	-
-	55816..55943	+	128	NuclAT_0	-	-
-	55816..55943	+	128	NuclAT_0	-	-
-	55816..55943	+	128	NuclAT_0	-	-
-	55876..55941	-	66	-	-	Antitoxin
I6L00_RS25760	55929..56078	+	150	Protein_60	plasmid maintenance protein Mok	-
I6L00_RS00360	56020..56145	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
I6L00_RS00365	56365..56595	+	231	WP_001426396.1	hypothetical protein	-
I6L00_RS25765	56593..56766	-	174	Protein_63	hypothetical protein	-
I6L00_RS00375	56836..57042	+	207	WP_000275859.1	hypothetical protein	-
I6L00_RS00380	57067..57354	+	288	WP_000107535.1	hypothetical protein	-
I6L00_RS00385	57473..58294	+	822	WP_001234469.1	DUF932 domain-containing protein	-
I6L00_RS00390	58591..59181	-	591	WP_001376243.1	transglycosylase SLT domain-containing protein	-
I6L00_RS00395	59523..59906	+	384	WP_001151566.1	conjugal transfer relaxosome DNA-binding protein TraM	-
I6L00_RS00400	60040..60717	+	678	WP_001348626.1	PAS domain-containing protein	-
I6L00_RS00405	60805..61032	+	228	WP_001254388.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaCTX-M-15 / mph(A) / sul1 / aadA5	senB	1..104896	104896

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T193067 WP_001372321.1 NZ_CP070097:56020-56145 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T193067 NZ_CP092679:c76247-75906 [Leptospira interrogans]
TTGGTAAAGAATAGAAACTATACTCCTGAAAAAGGAGATATAGTGTGGTTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT193067 NZ_CP070097:c55941-55876 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin