192993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4091419..4091921 Replicon chromosome
Accession NZ_CP070077
Organism Escherichia coli strain FDAARGOS_1371

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag I6L01_RS19195 Protein ID WP_000767829.1
Coordinates 4091667..4091921 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag I6L01_RS19190 Protein ID WP_001259255.1
Coordinates 4091419..4091670 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L01_RS19165 (4086597) 4086597..4087664 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
I6L01_RS19170 (4087664) 4087664..4088734 - 1071 WP_000108937.1 histidinol-phosphate transaminase -
I6L01_RS19175 (4088731) 4088731..4090035 - 1305 WP_021523144.1 histidinol dehydrogenase -
I6L01_RS19180 (4090041) 4090041..4090940 - 900 WP_021523143.1 ATP phosphoribosyltransferase -
I6L01_RS19185 (4091086) 4091086..4091136 - 51 WP_001364200.1 his operon leader peptide -
I6L01_RS19190 (4091419) 4091419..4091670 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
I6L01_RS19195 (4091667) 4091667..4091921 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
I6L01_RS19200 (4092004) 4092004..4092828 + 825 WP_000754758.1 SDR family oxidoreductase -
I6L01_RS19205 (4092874) 4092874..4093803 + 930 WP_023154044.1 LysR substrate-binding domain-containing protein -
I6L01_RS19210 (4094018) 4094018..4094080 + 63 WP_010723108.1 membrane protein YoeI -
I6L01_RS19215 (4094070) 4094070..4095428 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
I6L01_RS19220 (4095607) 4095607..4096665 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
I6L01_RS19225 (4096679) 4096679..4096906 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T192993 WP_000767829.1 NZ_CP070077:4091667-4091921 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T192993 NZ_CP092639:2592212-2592319 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT192993 WP_001259255.1 NZ_CP070077:4091419-4091670 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT192993 NZ_CP092639:c2592165-2592099 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References