Detailed information of TA system TA192957

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4082898..4083120
• Replicon: chromosome
• Accession: NZ_CP070071
• Organism: Escherichia coli strain FDAARGOS_1287

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6K17_RS20615
• Protein ID: WP_001295224.1
• Coordinates: 4083013..4083120 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4082898..4082956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K17_RS20590	4078286..4079269	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
I6K17_RS20595	4079266..4080270	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6K17_RS20600	4080300..4081571	-	1272	WP_001318103.1	aromatic amino acid transport family protein	-
I6K17_RS20605	4082047..4082154	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K17_RS20610	4082530..4082637	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4082898..4082956	-	59	-	-	Antitoxin
I6K17_RS20615	4083013..4083120	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6K17_RS20620	4083496..4083603	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K17_RS20625	4083690..4085369	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
I6K17_RS20630	4085366..4085557	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6K17_RS20635	4085554..4087125	-	1572	WP_204608585.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
I6K17_RS20640	4087398..4087586	+	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T192957 WP_001295224.1 NZ_CP070071:4083013-4083120 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T192957 NZ_CP092632:c5438186-5437803 [Klebsiella variicola subsp. variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT192957 NZ_CP070071:c4082956-4082898 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin