Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 769689..770191 | Replicon | chromosome |
| Accession | NZ_CP070071 | ||
| Organism | Escherichia coli strain FDAARGOS_1287 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | I6K17_RS04355 | Protein ID | WP_050491192.1 |
| Coordinates | 769976..770191 (+) | Length | 72 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | I6K17_RS04350 | Protein ID | WP_001259255.1 |
| Coordinates | 769689..769940 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K17_RS04325 (764867) | 764867..765934 | - | 1068 | WP_000080081.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| I6K17_RS04330 (765934) | 765934..767004 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| I6K17_RS04335 (767001) | 767001..768305 | - | 1305 | WP_063116140.1 | histidinol dehydrogenase | - |
| I6K17_RS04340 (768311) | 768311..769210 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| I6K17_RS04345 (769356) | 769356..769406 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| I6K17_RS04350 (769689) | 769689..769940 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| I6K17_RS04355 (769976) | 769976..770191 | + | 216 | WP_050491192.1 | Txe/YoeB family addiction module toxin | Toxin |
| I6K17_RS04360 (770274) | 770274..771098 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| I6K17_RS04365 (771144) | 771144..772073 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| I6K17_RS04370 (772288) | 772288..772350 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| I6K17_RS04375 (772340) | 772340..773698 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| I6K17_RS04380 (773877) | 773877..774935 | + | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| I6K17_RS04385 (774949) | 774949..775176 | + | 228 | WP_063116139.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 72 a.a. Molecular weight: 8549.82 Da Isoelectric Point: 9.8192
>T192931 WP_050491192.1 NZ_CP070071:769976-770191 [Escherichia coli]
MYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY
MYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY
Download Length: 216 bp
>T192931 NZ_CP092627:c4630157-4629846 [Salmonella enterica subsp. enterica serovar Thompson]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT192931 WP_001259255.1 NZ_CP070071:769689-769940 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT192931 NZ_CP092627:c4629845-4629555 [Salmonella enterica subsp. enterica serovar Thompson]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|