Detailed information of TA system TA192924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3322356..3323011
• Replicon: chromosome
• Accession: NZ_CP070069
• Organism: Bordetella pertussis strain FDAARGOS_1367

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: I6K97_RS15980
• Protein ID: WP_047122780.1
• Coordinates: 3322760..3323011 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: I6K97_RS15975
• Protein ID: WP_003809516.1
• Coordinates: 3322356..3322757 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K97_RS15945	3317539..3318561	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
I6K97_RS15950	3318698..3319735	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
I6K97_RS15955	3319755..3320945	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6K97_RS15960	3320948..3321463	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6K97_RS15965	3321613..3322092	-	480	WP_010930405.1	disulfide bond formation protein B	-
I6K97_RS15970	3322100..3322336	-	237	WP_010930404.1	membrane protein	-
I6K97_RS15975	3322356..3322757	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
I6K97_RS15980	3322760..3323011	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
I6K97_RS15985	3323066..3323947	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6K97_RS15990	3324172..3324618	+	447	WP_003819827.1	GFA family protein	-
I6K97_RS15995	3324703..3325767	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
I6K97_RS16000	3325904..3326485	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
I6K97_RS16005	3326720..3327850	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T192924 WP_047122780.1 NZ_CP070069:c3323011-3322760 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T192924 NZ_CP092627:845676-846074 [Salmonella enterica subsp. enterica serovar Thompson]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAAAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT192924 WP_003809516.1 NZ_CP070069:c3322757-3322356 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT192924 NZ_CP092627:845449-845676 [Salmonella enterica subsp. enterica serovar Thompson]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6