Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4058396..4058642 Replicon chromosome
Accession NZ_CP070063
Organism Escherichia coli strain FDAARGOS_1372

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag I6L02_RS19410 Protein ID WP_000956458.1
Coordinates 4058396..4058548 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 4058590..4058642 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L02_RS19385 4053667..4053990 - 324 WP_001246113.1 DUF3561 family protein -
I6L02_RS19390 4054040..4054645 - 606 WP_001173653.1 adenylyl-sulfate kinase -
I6L02_RS19395 4054645..4056072 - 1428 WP_001090357.1 sulfate adenylyltransferase subunit CysN -
I6L02_RS19400 4056074..4056982 - 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
I6L02_RS19405 4057234..4058271 + 1038 WP_000490435.1 alkaline phosphatase isozyme conversion aminopeptidase -
I6L02_RS19410 4058396..4058548 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 4058590..4058642 + 53 - - Antitoxin
I6L02_RS19415 4058813..4059547 - 735 WP_000039865.1 phosphoadenosine phosphosulfate reductase -
I6L02_RS19420 4059621..4061333 - 1713 WP_001290708.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
I6L02_RS19425 4061333..4063132 - 1800 WP_000211918.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T192894 WP_000956458.1 NZ_CP070063:c4058548-4058396 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T192894 NZ_CP092581:c826293-826105 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 53 bp

>AT192894 NZ_CP070063:4058590-4058642 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References