Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1221914..1222172 Replicon chromosome
Accession NZ_CP070063
Organism Escherichia coli strain FDAARGOS_1372

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6L02_RS05620 Protein ID WP_000809168.1
Coordinates 1221914..1222066 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1222115..1222172 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L02_RS05600 1217159..1217872 - 714 WP_001102393.1 acidic protein MsyB -
I6L02_RS05605 1217898..1218302 - 405 WP_000843689.1 DUF2541 family protein -
I6L02_RS05610 1218674..1220590 + 1917 WP_000516135.1 molecular chaperone DnaK -
I6L02_RS05615 1220679..1221809 + 1131 WP_001118464.1 molecular chaperone DnaJ -
I6L02_RS05620 1221914..1222066 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 1222115..1222172 + 58 - - Antitoxin
I6L02_RS05625 1222681..1223442 + 762 WP_001274832.1 outer membrane protein OmpK -
I6L02_RS05630 1223463..1224956 + 1494 WP_001337669.1 sulfatase-like hydrolase/transferase -
I6L02_RS05635 1225085..1226344 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T192872 WP_000809168.1 NZ_CP070063:c1222066-1221914 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T192872 NZ_CP092569:c1566587-1566405 [Enterococcus faecium]
ATGCCAATGACGCAAAATGAAATGGTGAAACTCCTAATTGAACACGGCGGCGTTAAAGTCAAAGGTGGGAAAGGATCTCA
TATAAAAGTGAGGTTTCCTGGAGTGAACCGGCCGATCATTGTTCCTCAGAAATTACCCAAAGGGACAGAAAACGGTATTT
TGAAGCAAGCAGGGTTGAAATAA

Antitoxin


Download         Length: 58 bp

>AT192872 NZ_CP070063:1222115-1222172 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References