Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 255140..255397 Replicon chromosome
Accession NZ_CP070063
Organism Escherichia coli strain FDAARGOS_1372

Toxin (Protein)


Gene name hokA Uniprot ID S1E8G5
Locus tag I6L02_RS01160 Protein ID WP_001135732.1
Coordinates 255140..255292 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 255349..255397 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L02_RS01135 251238..251897 + 660 WP_000747625.1 OmpA family lipoprotein -
I6L02_RS01140 252001..252975 + 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
I6L02_RS01145 253025..253735 - 711 WP_000190516.1 DUF3053 domain-containing protein -
I6L02_RS01150 254169..254459 + 291 WP_000455798.1 HTH-type transcriptional regulator -
I6L02_RS01155 254740..254952 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
I6L02_RS23325 255092..255163 + 72 WP_212734239.1 hypothetical protein -
I6L02_RS01160 255140..255292 - 153 WP_001135732.1 type I toxin-antitoxin system toxin HokA Toxin
- 255349..255397 + 49 - - Antitoxin
I6L02_RS01165 255615..257684 - 2070 WP_001291786.1 glycine--tRNA ligase subunit beta -
I6L02_RS01170 257694..258605 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
I6L02_RS01175 258700..259008 - 309 WP_000980157.1 YsaB family lipoprotein -
I6L02_RS01180 259183..260178 + 996 WP_001182669.1 O-acetyltransferase WecH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5998.28 Da        Isoelectric Point: 7.7169

>T192867 WP_001135732.1 NZ_CP070063:c255292-255140 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Download         Length: 153 bp

>T192867 NZ_CP092567:c2165690-2165481 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 49 bp

>AT192867 NZ_CP070063:255349-255397 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1E8G5

Antitoxin

Download structure file

References