Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2922606..2923299 Replicon chromosome
Accession NZ_CP070048
Organism Escherichia coli strain FDAARGOS_1290

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K20_RS14215 Protein ID WP_000415584.1
Coordinates 2923003..2923299 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K20_RS14210 Protein ID WP_000650107.1
Coordinates 2922606..2923001 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K20_RS14200 (2918470) 2918470..2920728 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
I6K20_RS14205 (2920866) 2920866..2922473 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
I6K20_RS14210 (2922606) 2922606..2923001 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K20_RS14215 (2923003) 2923003..2923299 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K20_RS14220 (2923504) 2923504..2923986 - 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K20_RS14225 (2924039) 2924039..2924431 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K20_RS14230 (2924583) 2924583..2925242 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
I6K20_RS14235 (2925239) 2925239..2926588 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K20_RS14240 (2926634) 2926634..2926966 - 333 WP_000917684.1 DUF2645 family protein -
I6K20_RS14245 (2927294) 2927294..2927875 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I6K20_RS14250 (2927906) 2927906..2928220 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T192844 WP_000415584.1 NZ_CP070048:c2923299-2923003 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T192844 NZ_CP092561:1962283-1962744 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTTGAAGCGCACAATTACGGTGTACGTAATTTATATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT192844 WP_000650107.1 NZ_CP070048:c2923001-2922606 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT192844 NZ_CP092561:1961947-1962270 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References