Detailed information of TA system TA192800

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 5186120..5186378
• Replicon: chromosome
• Accession: NZ_CP070045
• Organism: Escherichia coli strain FDAARGOS_1303

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6K33_RS25750
• Protein ID: WP_000809168.1
• Coordinates: 5186120..5186272 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	5186321..5186378 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K33_RS25730	5181365..5182078	-	714	WP_001102393.1	acidic protein MsyB	-
I6K33_RS25735	5182104..5182508	-	405	WP_000843687.1	DUF2541 family protein	-
I6K33_RS25740	5182880..5184796	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6K33_RS25745	5184885..5186015	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6K33_RS25750	5186120..5186272	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	5186321..5186378	+	58	-	-	Antitoxin
I6K33_RS25755	5186884..5187645	+	762	WP_001274823.1	outer membrane protein OmpK	-
I6K33_RS25760	5187665..5189158	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
I6K33_RS25765	5189287..5190546	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T192800 WP_000809168.1 NZ_CP070045:c5186272-5186120 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T192800 NZ_CP092547:c2499506-2499240 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT192800 NZ_CP070045:5186321-5186378 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin