Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2540938..2541631 Replicon chromosome
Accession NZ_CP070007
Organism Escherichia coli strain FDAARGOS_1288

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K18_RS12230 Protein ID WP_000415584.1
Coordinates 2540938..2541234 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K18_RS12235 Protein ID WP_000650107.1
Coordinates 2541236..2541631 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K18_RS12195 (2536026) 2536026..2536340 - 315 WP_000958598.1 putative quinol monooxygenase -
I6K18_RS12200 (2536371) 2536371..2536952 - 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
I6K18_RS12205 (2537271) 2537271..2537603 + 333 WP_000917684.1 DUF2645 family protein -
I6K18_RS12210 (2537649) 2537649..2538998 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K18_RS12215 (2538995) 2538995..2539654 - 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB -
I6K18_RS12220 (2539806) 2539806..2540198 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K18_RS12225 (2540251) 2540251..2540733 + 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K18_RS12230 (2540938) 2540938..2541234 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K18_RS12235 (2541236) 2541236..2541631 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K18_RS12240 (2541764) 2541764..2543371 + 1608 WP_001735743.1 ABC transporter substrate-binding protein -
I6K18_RS12245 (2543509) 2543509..2545767 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T192628 WP_000415584.1 NZ_CP070007:2540938-2541234 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T192628 NZ_CP092493:348960-349235 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT192628 WP_000650107.1 NZ_CP070007:2541236-2541631 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT192628 NZ_CP092493:349232-349591 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References