Detailed information of TA system TA192619

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 1061296..1061708
• Replicon: chromosome
• Accession: NZ_CP070007
• Organism: Escherichia coli strain FDAARGOS_1288

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: I6K18_RS05225
• Protein ID: WP_000132601.1
• Coordinates: 1061367..1061708 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	1061296..1061372 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K18_RS05215 (1058159)	1058159..1059748	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
I6K18_RS05220 (1059745)	1059745..1061139	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
- (1061296)	1061296..1061372	-	77	NuclAT_12	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_12	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_12	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_12	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_13	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_13	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_13	-	Antitoxin
- (1061296)	1061296..1061372	-	77	NuclAT_13	-	Antitoxin
I6K18_RS05225 (1061367)	1061367..1061708	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
I6K18_RS05230 (1061870)	1061870..1063249	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
I6K18_RS05235 (1063249)	1063249..1064295	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T192619 WP_000132601.1 NZ_CP070007:1061367-1061708 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T192619 NZ_CP092485:449528-449917 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT192619 NZ_CP070007:c1061372-1061296 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin