Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 926223..926481 Replicon chromosome
Accession NZ_CP070007
Organism Escherichia coli strain FDAARGOS_1288

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6K18_RS04485 Protein ID WP_000809168.1
Coordinates 926329..926481 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 926223..926280 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K18_RS04470 922615..923574 + 960 WP_000871674.1 hypothetical protein -
I6K18_RS04475 923612..924511 - 900 WP_001300855.1 transcriptional activator NhaR -
I6K18_RS04480 924577..925743 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 926223..926280 - 58 - - Antitoxin
I6K18_RS04485 926329..926481 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
I6K18_RS04490 926585..927715 - 1131 WP_001118464.1 molecular chaperone DnaJ -
I6K18_RS04495 927804..929720 - 1917 WP_000516135.1 molecular chaperone DnaK -
I6K18_RS04500 930096..930500 + 405 WP_000843584.1 DUF2541 family protein -
I6K18_RS04505 930526..931239 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T192617 WP_000809168.1 NZ_CP070007:926329-926481 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T192617 NZ_CP092478:1034926-1035075 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin


Download         Length: 58 bp

>AT192617 NZ_CP070007:c926280-926223 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References