Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2476963..2477185 Replicon chromosome
Accession NZ_CP069996
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag I6K30_RS12065 Protein ID WP_001295224.1
Coordinates 2477078..2477185 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2476963..2477029 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS12045 2472835..2473818 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
I6K30_RS12050 2473815..2474819 + 1005 WP_000103579.1 dipeptide ABC transporter ATP-binding subunit DppF -
I6K30_RS12055 2474849..2476120 - 1272 WP_001332306.1 aromatic amino acid transport family protein -
I6K30_RS12060 2476596..2476703 + 108 WP_000170745.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2476963..2477029 - 67 - - Antitoxin
I6K30_RS12065 2477078..2477185 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
I6K30_RS12070 2477561..2477668 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
I6K30_RS12075 2477754..2479433 - 1680 WP_000191567.1 cellulose biosynthesis protein BcsG -
I6K30_RS12080 2479430..2479621 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
I6K30_RS12085 2479618..2481189 - 1572 WP_001204957.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
I6K30_RS12090 2481462..2481650 + 189 WP_001063314.1 cellulose biosynthesis protein BcsR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T192593 WP_001295224.1 NZ_CP069996:2477078-2477185 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T192593 NZ_CP092466:3780576-3780794 [Citrobacter portucalensis]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 67 bp

>AT192593 NZ_CP069996:c2477029-2476963 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References